Timing and Specificity of Feed-Forward Inhibition within the LGN
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چکیده
منابع مشابه
Timing and Specificity of Feed-Forward Inhibition within the LGN
Local interneurons provide feed-forward inhibition from retinal ganglion cells (RGCs) to thalamocortical (TC) neurons, but questions remain regarding the timing, magnitude, and functions of this inhibition. Here, we identify two types of inhibition that are suited to play distinctive roles. We recorded excitatory and inhibitory postsynaptic currents (EPSCs/IPSCs) in TC neurons in mouse brain sl...
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Feed-forward inhibition in the hippocampal formation.
An overview of the current literature reveals a richness and complexity of anatomical, pharmacological and physiological features of the input systems to the archicortex. Evidence is cited to demonstrate that several afferent paths terminate on and directly excite hippocampal formation interneurons ("non-principal" cells) besides their contacts with pyramidal and granule cells (principal cells)...
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Inhibitory interneurons across diverse brain regions commonly exhibit spontaneous spiking activity, even in the absence of external stimuli. It is not well understood how stimulus-evoked inhibition can be distinguished from background inhibition arising from spontaneous firing. We found that noradrenaline simultaneously reduced spontaneous inhibitory inputs and enhanced evoked inhibitory curren...
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Neurons receive a large number of excitatory and inhibitory synaptic inputs whose temporal interplay determines the spiking behavior. On average, excitation and inhibition balance each other, such that spikes are elicited by fluctuations [1]. In addition, it has been shown in vivo that excitation and inhibition are correlated, with inhibition lagging excitation only by few milliseconds (∼6 ms),...
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ژورنال
عنوان ژورنال: Neuron
سال: 2005
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2005.01.033